Search results for "PsyArXiv|Neuroscience"
showing 10 items of 8055 documents
L'olfaction comme fenêtre sur les états affectifs premiers: Rousseau s'est-il mépris?
2007
L’utilisation des mécanismes de maintien de l’information verbale en mémoire de travail chez l’enfant de 8 ans
2010
La mémoire de travail est une forme de mémoire immédiate qui permet de retenir des informations tout en effectuant simultanément un traitement sur ces informations ou sur d’autres informations. Elle est indispensable dans la vie quotidienne, par exemple sans elle nous serions incapable de comprendre une phrase ou de résoudre une opération. Les informations stockées dans cette mémoire ne peuvent être maintenues que pendant un très bref instant (± 2 secondes). Cependant, il est possible de les retenir pendant une plus longue durée en utilisant des mécanismes de maintien. Actuellement deux mécanismes de maintien ont été mis en évidence. Le premier est un mécanisme de répétition subvocale, qui …
P3‐271: Presenilin‐1 (PS1) and amyloid precursor protein (APP) mutations present in mouse models of Alzheimer's disease in their response to γ‐secret…
2009
P3‐039: Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus
2011
Loss of neurons in the hippocampus correlates with memory impairment in AD. Significant early reduction in the numerical density of hippocampal SOM interneurons was found in single (APPswe) and double (APPswe/ PS1dE9 and APPswe/TauP301S-G272V) transgenic models based on APP over expression and amyloid production. However, this inhibitory population was unaffected in age-matched single PS1 and tau transgenic mice as well as nontransgenic controls. Whereas SOM neuron loss in APPswe/PS1dE9 was associated to the onset of extracellular amyloid pathology in double APP/ tau mice this loss preceded plaque formation. Conclusions: As in human AD, somatostatin cell loss is a common early pathological …
P3‐183: Role of RCAN1, a gene involved in the adaptation to oxidative stress, in Alzheimer's pathology
2011
2016
Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons. Here we provide, using immunohistochemistry, a detailed study on the distribution of Cygb in the mouse brain. While Cygb is a cytoplasmic protein in active cells of the supportive tissue, in neurons it is located in the cytoplasm and the nucleus. We found the expression of Cygb in all brain regions, although only a fraction of the neurons was Cygb-positive. Signals were of different intensity ranging from faint to very intense. Telencephalic neurons in all laminae of the cerebral cortex, in the olfactory bulb (in particular periglom…
Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies
2008
In this review, the functional interactions between serotonin (5-HT) and dopamine (DA) neuronal systems are discussed with the focus on microdialysis studies in the rodent brain (mainly rats). 5-HT by itself is involved both directly and indirectly via actions on complex neuronal circuitry, in the regulation of DA release through multiple 5-HT receptors, playing a critical role in the development of normal and abnormal behaviours. Recent evidence suggests that dysfunction of dopaminergic and serotoninergic neurotransmitter systems contributes to various disorders including depression, schizophrenia, Parkinson's disease and drug abuse. Here we summarize recent neurochemical works that have e…
Reduced cerebral DOPA uptake in adult patients suffering from phenylketonuria
2006
Equilibrium in [18F]fallypride PET
2010
Persistent inflammation alters the function of the endogenous brain stem cell compartment
2008
Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed. Despite evidence of increased neurogenesis upon acute inflammatory insults (e.g. ischaemic stroke), the plasticity of the endogenous brain stem cell compartment in chronic CNS inflammatory disorders remains poorly characterized. Here we show that persistent brain inflammation, induced by immune cells targeting myelin, extensively alters the proliferative and migratory properties of subventricular zone (SVZ)-resident NPCs in vivo leading to significant accumulation…